Chromatography Resin Market

Chromatography Resin Market Outlook (2024 to 2034)

Revenue from the global chromatography resin market is calculated at US$ 2.39 billion in 2024 and has been forecast to increase at a 5.3% CAGR to reach US$ 4.01 billion by the end of 2034.

Two phases form the foundation of the chromatography theory: the stationary phase, facilitating sample purification, and the mobile phase, carrying the sample. This stationary phase comprises chromatographic resins.

Chromatography assumes various forms depending on the resin utilized. Size exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), ion exchange chromatography (IEX), and affinity chromatography represent the primary types.

Chromatography resins are instrumental in the separation and purification of proteins and bio-molecules across biotechnology, food production, environmental analysis, and pharmaceuticals. Chromatography resin market growth is driven by increased funding for research and development in the pharmaceutical industry and the rising demand for biosimilars.

Key Market Growth Drivers

• Two primary advanced techniques gaining popularity are high-performance liquid chromatography (HPLC) and ultra-high-performance chromatography (UHPLC) due to their enhanced precision and separation efficiency. These technologies significantly contribute to market expansion.
• The increasing adoption of lightweight materials across many industries is another major factor boosting chromatography resin sales.
• A growing focus on sustainability is a notable trend in the chromatography resin market, expanding its scope.
• Increasing investments in healthcare infrastructure are projected to create lucrative opportunities for chromatography resin producers.
• The continuous focus on drug development and research is escalating the demand for chromatography resins.
• The expansion of biopharmaceutical production is also boosting the demand for chromatography resins.
• Increasing awareness of chromatography techniques' usage fosters their adoption across various industries.
• Chromatography procedures play a critical role in maintaining the safety and quality of food and beverages.

Report Attribute	Detail
Chromatography Resin Market Size (2024E)	US$ 2.39 Billion
Forecasted Market Value (2034F)	US$ 4.01 Billion
Global Market Growth Rate (2024 to 2034)	5.3% CAGR
East Asia Market Share (2024E)	26.3%
North America Market Value (2024E)	US$ 435.5 Million
Pharmaceuticals & Biotechnology Segment Value (2034F)	US$ 2.38 Billion
Key Companies Profiled	Bio-Rad Laboratories; Agilent Technologies; Pall Corporation; Waters Corporation; Kaneka Corporation; Mitsubishi Chemical Corporation; Merck KGaA; Expedeon Ltd.; GE Healthcare; Perkin Elmer Inc.; Life Technology Corporation; Knauer GmbH; Shimadzu Corporation; Avantor Performance Materials Inc.; W.R. Grace & Co.

Which Aspects are Positively Influencing the Market for Chromatography Resins?

“Growing Demand for Specific Compound Analysis in Biotechnology and Pharmaceutical Sectors”

Continuous technological advancements in chromatography resin production are generating fresh growth prospects for industry players. The demand for efficient and suitable chromatography resins is rising due to the adoption of innovative chromatography techniques, such as ion exchange, affinity, hydrophobic interaction, and size exclusion. These methodologies reduce processing durations, enhance analytical performance, and optimize separation efficiency. The increasing emphasis on research and development (R&D), alongside the rise in funding for R&D, is forecasted to drive the demand for chromatography resins.

Chromatography resins play a pivotal role in analyzing and isolating specific compounds in biotechnology, pharmaceuticals, and chemicals for research purposes. With the rise in R&D expenditures, the chromatography resin market is projected to support experimentation, drug discovery, and material analysis.

What Challenges Do Producers of Chromatography Resins Need to Tackle?

“High Initial Investment and Maintenance Expenditures”

Key factor that becoming a major roadblock to the growth of the market is the high-cost requirement in the initial phase. Chromatographic separation equipment, including columns, pumps, detectors, and related gear are expensive to acquire and maintain. Also, quality chromatography resin is rather costly. This issue, particularly for small firms and research laboratories with limited resources, prohibits them from employing excellent chromatographic procedures.

Chromatography systems and equipment require frequent maintenance to ensure proper functioning and accuracy. Regular maintenance procedures can cause downtime, which influences production and overall process efficiency. Industries that rely significantly on continuing operations experience interruptions, disrupting production schedules. The price of normal maintenance, the time spent procuring new components, and the total operational costs restrict the expansion of the chromatography resin market size.

Country-wise Insights

East Asia is set to hold 26.3% share of the global market in 2024. In North America, demand for chromatography resins is projected to rise at 6.5% CAGR from 2024 to 2034.

Which Chromatography Resin Market Trends are Significant in the United States?

“Research Efforts to Enhance Resin Performance and Improve Chromatography Systems”

Attribute	United States
Market Value (2024E)	US$ 316.6 Million
Growth Rate (2024 to 2034)	7.1% CAGR
Projected Value (2034F)	US$ 626.4 Million

In the North American region, the United States is poised to hold 72.7% revenue share in 2024. The United States is among the countries that are well-known for their technological developments and innovations in chromatography techniques. Research efforts aimed at enhancing resin performance and improving chromatography systems are ongoing. More opportunities are projected to emerge for industry players in the United States in the coming years.

• In July 2022, Bio-Rad Laboratories, located in the United States, launched the EconoFit Low-Pressure Prepacked Chromatography Column Packs. The EconoFit columns are developed for resin screening, allowing clients to create protein purification processes and select the best chemistry for each target.

Why is China Becoming the Center of Attention for Chromatography Resin Producers?

“Growing Emphasis on Green Chemistry Initiatives”

Attribute	China
Market Value (2024E)	US$ 347.3 Million
Growth Rate (2024 to 2034)	6.5% CAGR
Projected Value (2034F)	US$ 651.1 Million

China holds a dominant position in the East Asia market, accounting for a significant chromatography resin market share. Known for its advancements in pharmaceutical manufacturing and biotechnology, China presents an attractive and lucrative opportunity for companies operating in the market. The growing pharmaceutical and biotechnology sectors in the country are driving the demand for chromatography resins, particularly for purification and monoclonal antibodies. The rising implementation of green chemistry initiatives is fostering the increased adoption of chromatography resins in China.

Category-wise Insights

Based on type, the market is segmented into natural, synthetic, and inorganic. Natural polymers contain agarose, cellulose, and dextran, among others, whereas synthetic resins include ion exchange resins. Natural and synthetic chromatographic resins are preferred over inorganic in many industries.

Which End Use Accounts for High Demand for Chromatography Resins?

“Growing Need for High-Quality Monoclonal Antibodies in Pharmaceutical and Biotechnology Sectors”

Attribute	Pharmaceutical & Biotechnology
Segment Value (2024E)	US$ 1.35 Billion
Growth Rate (2024 to 2034)	5.9% CAGR
Projected Value (2034F)	US$ 2.38 Billion

Growth of the pharmaceutical and biotechnology sectors is driving up sales of chromatography resins, fueled by the rising demand for top-notch, uncontaminated monoclonal antibodies, vaccines, biologics, and therapeutic proteins. Chromatography resins are serving as indispensable tools for efficient purification within these processes.

Both the chromatography resin market and the pharmaceutical and biotechnology sectors are exhibiting steady growth, driven by advancements in genetic engineering, synthetic biology, and related fields. Chromatography resins play a pivotal role in the purification and isolation of genetic enzymes, modified proteins, and assorted biomolecules for diverse applications.

What Advantage Does Affinity Chromatography Offer Over Other Techniques in Protein Purification?

“Enhanced Resolution and Selectivity in Protein Purification Associated with Affinity Chromatography”

Based on technique, the market is segmented into ion exchange, affinity, hydrophobic interaction, and size exclusion. Affinity chromatography is expected to retain a significant share of the market revenue and expand due to the increasing demand for protein A, facilitating effective antibody purification. Affinity chromatography enhances protein purification processes by enhancing resolution, capacity, and selectivity. One advantage is its utilization of a protein's inherent biological structure or function to facilitate purification, driving the growth of this segment.

• In March 2020, Avantor, Inc., a leading global provider of mission-critical products and services to clients in the health sciences, advanced technologies, and applied materials sectors, introduced a novel recombinant Protein A affinity chromatography resin for purifying antibodies during mAb manufacture.

Competitive Landscape

Key players in the chromatography resin industry include Bio-Rad Laboratories, Agilent Technologies, Pall Corporation, Waters Corporation, Kaneka Corporation, Mitsubishi Chemical Corporation, Merck KGaA, Expedeon Ltd., GE Healthcare, Perkin Elmer Inc., Life Technology Corporation, Knauer GmbH, Shimadzu Corporation, Avantor Performance Materials Inc., and W.R. Grace & Co.

• In November 2023, Cytiva announced a new technique called Protein Select, which the firm claims would streamline and speed recombinant protein purification. Amanda Halford, president of bioprocess, says that the self-cleaving traceless tag and complementary affinity chromatography resin standardize purification for every protein, eliminating the need for distinct affinity binding partners for each protein.
• In September 2023, Shimadzu, a major chromatography equipment manufacturer, introduced its new Nexera LC-40 HPLC system. The Nexera LC-40 is intended to deliver high-performance and dependable chromatography analysis across a wide range of applications, including pharmaceutical research, food safety, and environmental testing.
• In March 2020, Tosoh Bioscience LLC, which manufactures chromatographic solutions for biomolecule separation and purification, released SkillPak 1 mL and 5 mL pre-packed columns. These process development columns are designed to speed up the synthesis and resin screening of monoclonal antibodies, antibody constructs, oligonucleotides, proteins, and viruses.

Fact.MR provides detailed information about the price points of key manufacturers of chromatography resins positioned across the world, sales growth, production capacity, and speculative technological expansion, in this new market report.

Segmentation of Chromatography Resin Market Research

• By Type :

  • Natural
  • Synthetic
  • Inorganic

• By Technique :

  • Ion Exchange
  • Affinity
  • Hydrophobic Interaction
  • Size Exclusion

• By End Use :

  • Pharmaceutical & Biotechnology
  • Food & Beverages

• By Region :

  • North America
  • Latin America
  • East Asia
  • South Asia & Pacific
  • Western Europe
  • Eastern Europe
  • Middle East & Africa